Figure 2.
Lineage III La Crosse virus (LACV) strains shows reduced pathogenesis in three-week-old Swiss Webster mice when compared to other lineages. In this study, three-week-old mice (n = 14/group) were challenged intraperitoneally with 103 plaque forming units (PFU) of virus (a) survival and (b) weight change measured daily for 21 days postinfection (DPI). (c) Virus was detected in brains harvested five DPI but not three DPI. Lineage III strains presented with reduced neuroinvasiveness and the lowest brain titers among all lineages studied. Each data point plotted represents the mean values, and error bars indicate standard deviation. Statistical significance among groups was analyzed by log-rank (Mantel-Cox) test in (a), and two-way ANOVA with Tukey’s multiple comparison test in (b,c). Statistically significant values are denoted by * (p < 0.05).