Figure 4.
Subgroup ROC analysis for iCCA diagnosis. (A–C) Diagnostic performance of five parameters in healthy control subgroup, benign liver lesions subgroup and other liver malignancies subgroup. Three-marker model also demonstrated a preferable diagnostic efficacy than other parameters in three subgroups (Tables S3–S5). (D,E) Diagnostic efficacy of three-marker model for iCCA with different AJCC stage. Three-marker model still possessed a good diagnostic efficacy even in early stage iCCA. (F) Diagnostic efficacy of two-miR model and three-marker model for iCCA in CA19-9negative cohort.