Independent components discriminant analysis proportions plot calculated after source signal extraction for the data obtained by RP chromatography and corresponding F-value associated with the Wilks’ lambda characterizing the discrimination of the predefined groups: (A) to discriminate the fat content of the diet. Separation of the HD groups from the CD-group based on IC1, IC2 and IC5; (B) to discriminate the protein content diet sequences, partial separation of the NP-HP group with HP-NP group based on IC1, IC2 and IC3; (C) to discriminate the diets, whatever the intervention period. Separation of the HP, NP and CD groups based on IC1, IC2 and IC5. CD: control diet; HD: high-fat, hypercaloric diet whatever the protein content of the diet; NP-HP: NPHD at P1 and HPHD P2 period; HP-NP: HPHD at P1 and NPHD P2 period; HP: HPHD at either P1 or P2 period; NP: NPHD at either P1 or P2 period; QC: quality controls.