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. 2021 Apr 1;9(4):340. doi: 10.3390/vaccines9040340

Figure 4.

Figure 4

Representative histology of differences between unimmunized SARS-CoV-2 infected controls (A,C,E,G) and infected hamsters vaccinated with SolaVAX prepared SARS-CoV-2 virus and CpG 1018 adjuvant (B,D,F,H). Images A-F are taken at 3 dpi and images G-H are taken at 7 dpi. (A) Trachea with dense submucosal lymphocytic and neutrophilic inflammation infiltrating mucosal epithelium (arrow) and accumulation of neutrophils within the tracheal lumen (arrowhead). (B) Trachea with mild submucosal lymphocytic inflammation. (C) Large bronchus with dense lymphocytic and suppurative inflammation in the interstitium (arrow) and accumulation of neutrophils in the lumen with loss of mucocal epithelium (arrowhead). (D) Large bronchus minimally affected by inflammation (arrow). (E) Effacement of lung alveolar tissue by consolidating interstitial pneumonia (arrow) and overall decrease in alveolar air space (arrowhead). (F) Interstitial pneumonia increasing alveolar wall thickness (arrowhead) without compromising alveolar air space (arrowhead). (G) Lymphocytic interstitial pneumonia surrounds dense pneumocyte epithelial regeneration (arrows) at day 7 of infection. (H) Minimal evidence of interstitial pneumonia (arrow) and an absence of epithelial regeneration.