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. 2021 Apr 1;14(4):310. doi: 10.3390/ph14040310

Table 1.

Box–Behnken design matrix and experimental values obtained for resolutions and run time.

Run Factors Responses
X1 X2 X3 Rs3–4 Rs4–5 Rs5–6 Rs6–7 Run Time (min)
1 0 0 0 1.50 3.62 3.34 1.74 2.761
2 1 0 1 1.22 3.68 2.72 1.31 2.326
3 0 0 0 1.77 4.53 4.10 2.02 2.775
4 0 −1 1 1.08 2.46 2.12 1.22 2.658
5 −1 0 −1 2.01 3.93 3.68 2.20 3.574
6 −1 0 1 1.00 2.83 2.79 1.27 2.659
7 0 1 1 1.18 3.53 3.08 1.47 2.210
8 0 0 0 1.36 3.62 2.89 1.41 2.759
9 0 1 −1 2.35 5.40 4.81 2.83 2.924
10 1 −1 0 1.25 3.60 3.49 1.75 2.892
11 0 −1 −1 1.80 3.88 4.01 2.35 3.699
12 −1 −1 0 1.13 3.38 3.05 1.61 3.242
13 −1 1 0 1.49 3.76 3.01 1.58 2.705
14 1 1 0 1.82 4.30 3.63 1.88 2.298
15 1 0 −1 2.02 4.33 4.91 2.92 3.199