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. 2021 Mar 29;11(4):435. doi: 10.3390/brainsci11040435

Figure 3.

Figure 3

The schematic model of “Common Pathways Underlying Drug dependence” is an output (FDR p < 0.01) of the Wikipathway functional pathway analysis [39]. Red background of the genes indicates significant upregulation and green background downregulation of the gene in the dorsomedial thalamus of the AUD subjects. The schema is originally constructed by Li et al. [40]: glutamate and dopamine neuroactive ligand-receptor interactions trigger long-term potentiation, MAPK and GnRH signaling and gap junction regulation.