Table 1.

16 genes that were differentially expressed (FDR p < 0.05) in the dorsomedial thalamus of AUD subjects and have also been found to be significantly (FDR p < 10⁻⁸) associated with AUD or alcohol consumption phenotypes in at least two independent recent GWAS studies (2019–2000: Evangelou et al., 2019 [4]; Liu et al., 2019 [6]; Sanchez-Roige et al., 2019 [7]; Zhou et al., 2020 [8]; Thompson et al., 2020 [9]; Gelernter et al., 2019 [34]; Karlsson et al., 2019 [35]). The highest GWAS p-value has been given. More detailed information about GWAS phenotypes and p-values can be found in Supplementary Table S6.

Gene Symbol	Gene Alias/Full Name	Gene Array Fold Change	GWAS Link with Alcohol Consumption Phenotype	Highest GWAS p Value
ARID4A	AT rich interactive domain 4A	4.43	[6,8]	1 × 10−8
ARPC1B	Actin related protein 2/3 complex subunit 1B	3.08	[4,6]	3 × 10−10
CADM2	Cell adhesion molecule 2	2.87	[4,6,8,35]	2 × 10−17
CRHR1	Corticotropin releasing hormone receptor 1	6.27	[7,34]	1.63 × 10−9
DPP6	Dipeptidyl-peptidase 6	2.56	[4,6,8,35]	6 × 10−14
DRD2	Dopamine receptor D2	5.22	[5,6,8,9,35]	5.13 × 10−15
FTO	Alpha-ketoglutarate dependent dioxygenase	7.75	[4,5,8]	1.11 × 10−19
MAPT	Microtubule associated protein tau	5.2	[4,7]	5 × 10−23
OTX2	orthodenticle homeobox 2	2.65	[4,6]	2 × 10−12
POLR3H	RNA polymerase III subunit H	7.09	[6,35]	5 × 10−9
SEZ6L2	Seizure related 6 homolog like 2	8.25	[4,6,35]	3 × 10−15
SORL1	Sortilin-related receptor 1	3.46	[6,8]	2.24 × 10−9
SYT14	Synaptotagmin 14	2.68	[4,8]	1 × 10−10
TCF4	Transcription factor 4	5.39	[4,6,8,35]	1 × 10−10
ADH1B	alcohol dehydrogenase 1B	−3.54	[4,5,6,8,9,34,35]	2.2 × 10−308
ADH7	alcohol dehydrogenase 7	−2.48	[6,35]	2 × 10−22
EMCN	Endomucin	−3.2	[6,35]	3 × 10−23
GCKR	glucokinase regulator	−4.7	[4,5,6,7,8,9,35]	2 × 10−60
SIX3	SIX homeobox 3	−2.82	[5,8]	2.26 × 10−15