Table 2.
Standard biochemical characteristics at baseline by heart failure and pulmonary hypertension status.
| Control (n = 72) | noPH-HF (n = 27) | PH-HF (n = 33) | p-Value a | p-Value b | |
|---|---|---|---|---|---|
| Biochemical Parameters | |||||
| Hemoglobin, g/L | 142 ± 10 | 132 ± 15 | 134 ± 15 | NS | <0.01 |
| Leucocytes, count × 109/L | 5.8 ± 1.3 | 7.6 ± 2.0 | 7.4 ± 1.8 | NS | <0.01 |
| Urea, nM | 6.1 ± 1.4 | 10.1 ± 3.7 | 12.8 ± 4.9 | <0.01 | <0.01 |
| Estimated glomerular filtration rate, mL/min | 83 ± 21 | 55 ± 25 | 46 ± 20 | NS | <0.01 |
| NT-proBNP, ng/mL | 57 ± (30–90) | 1273 (733–3377) | 3704 (1877–5954) | <0.01 | <0.01 |
| Elevated troponin, n (%) | 0 (0) | 4 (15) | 6 (18) | NS | <0.01 |
| Asparagine aminotransferase, U/L | 21 ± 6 | 24 ± 12 | 24 ± 8 | NS | NS |
| Alanine aminotransferase, U/L | 40 ± 9 | 42 ± 16 | 39 ± 11 | NS | NS |
| Alkaline phosphatase, U/L | 71 ± 18 | 112 ± 53 | 99 ± 42 | NS | <0.01 |
| Total bilirubin, μM | 11 ± 5 | 12 ± 6 | 13 ± 9 | NS | NS |
| Uric acid, μM | 281 ± 77 | 394 ± 127 | 468 ± 136 | 0.04 | <0.01 |
| Total cholesterol, mM | 5.1 ± 0.8 | 4.4 ± 0.9 | 3.9 ± 1.2 | NS | <0.01 |
| HDL-cholesterol, mM | 1.5 ± 0.4 | 1.0 ± 0.3 | 0.9 ± 0.2 | NS | <0.01 |
| LDL-cholesterol, mM | 3.2 ± 0.7 | 2.6 ± 0.7 | 2.4 ± 1.1 | NS | <0.01 |
| Triglycerides, mM | 1.1 ± 0.5 | 2.0 ± 1.3 | 1.4 ± 0.7 | NS | <0.01 |
| Glucose, mM | 4.6 ± 0.5 | 7.4 ± 3.1 | 7.0 ± 1.9 | NS | <0.01 |
| HOMA-IR | 23 ± 12 | 65 ± 40 | 45 ± 26 | 0.03 | <0.01 |
| C-reactive protein, μg/mL | 1.0 (0.5–2.1) | 2.9 (1.2–11.3) | 3.4 (2.0–9.3) | NS | <0.01 |
| TNF-α, pg/mL | 1.1 ± 0.4 | 2.1 ± 1.0 | 2.2 ± 0.6 | NS | <0.01 |
| Myeloperoxydase, ng/mL | 16.9 ± 6.7 | 23.1 ± 8.5 | 23.2 ± 15.0 | NS | <0.01 |
a refers to p values comparing noPH-HF and PH-HF; b refers to p values comparing all three groups. Groups were compared using ANOVA, Kruskal Wallis, Chi-square or Fisher’s exact test where appropriate.