Figure 2.

Venn diagrams of the target genes identified by TargetScan and miRDB for the six most significant miRNAs (A). Top canonical pathway identified on IPA from the list of the target genes in the intersections of the Venn diagram of the six most significant miRNAs (B). The significance values (p-value of overlap) for the canonical pathways are calculated by the right-tailed Fisher’s Exact Test. The x-axis displays the -log of the p-value. The orange line indicates the significance threshold. Gray bars indicate pathways for which no prediction of activation or inhibition can be made due to insufficient evidence in the Knowledge Base for confident activity predictions across datasets. White bars indicate pathways with z-scores at or very close to 0.