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Noise exposure upregulates cochlear expression of high mobility group box 1 (HMGB1) and 4-HNE. (A) Western blot analysis of cochlear HMGB1 and 4-HNE expression after noise exposure. (B) Quantification of the time course of cochlear HMGB1 and 4-HNE expression (n = 4 [refers to 8 cochleae from 4 animals] for each bar). The results are expressed as the mean ± SEM. * p < 0.05; ** p < 0.01; N = a control mouse group not exposed to noise; SEM = standard error of the mean.
