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. 2021 Mar 28;10(4):360. doi: 10.3390/antibiotics10040360

Table 1.

Characteristics of included studies.

Studies Animal Model (n) Location of Implant Placement Follow-Up Analysis Methods Conclusions
Zhang et al. [19] Beagle dog model
(3)		 Mandible (premolars and molar area) 4 weeks
  • -

    Micro-CT.

  • -

    Bone volume (BV).

  • -

    Bone Mineral Density (BMD).

  • -

    Trabecular Thickness (Tb.Th).

  • -

    Trabecular Number (Tb.N).

 The SLA-Ta (Tantalum) surface showed excellent antibacterial activity against Porphyromonas gingivalis and Fusobacterium nucleatum involved in peri- implant infections.
Zhou et al. [20] New Zealand rabbit model
(24)		 Femoral shafts area 8 weeks
  • -

    Histological analysis of the BIC.

  • -

    Pull-out force of the metallic Ti wires with and without coatings.

  • -

    Bacterial counting method

 The incorporation of Strontium (Sr) induces a better osseointegration, but it did not affect its angiogenic and antibacterial capabilities.
Ding et al. [21] Wild mice model
(20)		 The upper first right molar area 8 weeks
  • -

    Micro-CT

  • -

    BIC

  • -

    Bone Area (BA)

 The doxycycline (DC)-treated Hydroxyapatite (HA)-coated implant surface promotes bone apposition around the implant.
Nie et al. [22] Rat model
(36)		 Femur 3 weeks
  • -

    Staphylococcus aureus concentration.

  • -

    Micro-CT.

  • -

    BIC.

 The bacitracin (BC) on the Ti surface demonstrated potential prophylaxis against Ti implant-associated infection. Further, the BC-coated Ti showed potential towards osteoinductvity in a rat model.
Lee et al. [23] Hound Labrador dogs
(12)		 Mandibular premolar area 8 weeks
  • -

    Radiographic recordings (Presence of a periimplant radiolucent zone).

  • -

    BIC

  • -

    BMD

 Human bone morphogenetic protein- 2 (rhBMP-2)-coated tita- nium porous oxide implants induce significant bone formation.
Susin et al. [24] Hound Labrador dogs
(6)		 Mandibular premolar area 8 weeks
  • -

    Radiographic recordings (Presence of a periimplant radiolucent zone).

  • -

    BIC

  • -

    BMD

 rhBMP-7 coated onto Ti porous-oxide surface implants induces clinically relevant local bone formation including osseointegration and vertical augmentation of the alveolar ridge.

BV, bone volume; BMD, bone mineral density; Tb.Th, trabecular thickness; Tb.N, trabecular number; BIC, bone to implant contact; Ti, titanium; Ta, tantalum; Sr, strontium; BA, bone area; DC, doxycycline; BC, bacitracin; HA, hydroxyapatite; rhBMP, human bone morphogenetic protein.