Table 1.
Fecal microbiota transplantation studies in hypertensive animals and humans.
| Author | Donor | Recipient | Nutritional Treatment |
Primary Outcome | p | Year |
|---|---|---|---|---|---|---|
| Mell et al. [80] | Dahl salt-resistant rats | Dahl salt-sensitive rats | high-salt diet | ↑ BP ↓ Na+ excretion Shorter life span |
<0.05 <0.01 <0.05 |
2015 |
| Durgan et al. [81] | Hypertensive rats with OSA | Normotensive rats with OSA | Donor: high-fat diet Recipient: normal diet |
↑ BP | <0.05 | 2016 |
| Adnan et al. [82] | SH rats | Normotensive WKY rats | N.A. | ↑ BP ↑ F to B ratio |
0.02 0.042 |
2017 |
| Li et al. [31] | Hypertensive subjects | Germ-free mice | N.A. | ↑ systolic BP ↑ diastolic BP |
0.018 0.019 |
2017 |
| Toral et al. [83] | SH rats | Normotensive WKY rats | N.A. | ↑ systolic BP ↑ diastolic BP ↑ plasma noradrenaline ↑ TNF-α, IL-1β, IL-6 |
<0.01 <0.05 <0.05 <0.05 |
2019 |
| Toral et al. [84] | Normotensive WKY rats | SH rats | N.A. | ↓ systolic BP ↓ NADPH oxidase activity ↓ NOX-1 m-RNA ↓ p22phox and p47phox m-RNA |
<0.01 <0.01 <0.05 <0.05 |
2019 |
Abbreviations: ↑, increase; ↓, decrease; B, Bacteroidetes; BP, blood pressure; F, Firmicutes; IL, interleukin; N.A., not applicable; NADPH, Nicotinamide adenosine dinucleotide phosphate; OS, oxidative stress; OSA, obstructive sleep apnea; TNF, tumor necrosis factor; SH, spontaneously hypertensive; WKY, Wistar-Kyoto.