Table 3.

Multinomial Poisson logistic regression results (n = 4959) showing association between polygenic risk score for 17 related phenotypes with non-suicidal self-harm and suicide attempt

	Non-suicidal self-harm		Suicide attempt
Exposure	RR	95% CI	RR	95% CI
ADHD	1.10	1.02, 1.19	1.21	1.09, 1.34
Alcohol	1.07	0.98, 1.16	0.99	0.89, 1.10
Anorexia	1.01	0.93, 1.09	1.12	1.01, 1.23
Anxiety	0.98	0.90, 1.05	0.96	0.87, 1.06
ASC	1.09	1.01, 1.18	1.09	0.98, 1.20
Cannabis	1.03	0.95, 1.11	0.99	0.89, 1.09
Conscientiousness	1.02	0.94, 1.10	1.00	0.90, 1.11
Depression	1.17	1.08, 1.27	1.47	1.32, 1.63
Education	1.04	0.96, 1.12	0.97	0.88, 1.07
Extraversion	0.98	0.91, 1.06	0.97	0.88, 1.08
Income	1.01	0.93, 1.09	0.90	0.81, 0.99
IQ	1.14	1.06, 1.24	1.02	0.92, 1.13
Neuroticism	1.16	1.08, 1.26	1.27	1.14, 1.40
Agreeableness	0.94	0.87, 1.02	0.93	0.84, 1.03
Schizophrenia	1.05	0.97, 1.14	1.06	0.96, 1.17
Openness	1.01	0.93, 1.09	1.02	0.92, 1.13
Suicide attempt	1.07	0.99, 1.15	1.10	0.99, 1.21

Reference category: no self-harm. Polygenic scores standardised to have mean 0 and standard deviation 1 so the RR represents the change in risk of the outcome per 1 standard deviation increase in polygenic risk score

ADHD attention deficit/hyperactivity disorder, ASC autism spectrum conditions