Figure 3.

3D arrays of AuNPs on/embedded in flexible substrates/matrices. (a) 3D Nanocups on PDMS: Schematic illustration of the fabrication steps of the flexible 3D Au nanocups platform; sensitivity measurements leading to a value of 195 nm/RIU; and reflectance response after human IgG immobilization and specific anti-human IgG detection Adapted from ref. [80] Copyright (2017) with permission from Springer Nature. (b) Stimuli-responsive hydrogel embedding AgNPs: Schematic illustration of detection principle of LSPR-based optical enzyme biosensor. Reproduced from Ref. [81] Copyright (2008), with permission from Elsevier. (c) PEGDA hydrogel nanocomposite embedding AuNPs: Schematics of the functionalization procedure involving citrate displacement with a cysteamine modification of AuNPs and the subsequent sulfo-NHS biotin grafting on the available amino groups of cysteamine within the nanocomposite, and LSPR λ_max (black squares) as a function of the biotin concentration (from 25 μM to 10 mM). Adapted from [17] Copyright (2021), with permission from AIP Publishing.