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. 2021 Apr 1;9(4):738. doi: 10.3390/microorganisms9040738

Figure 2.

Figure 2

Percentage of CSF+ pneumococcal meningitis cases in the mature PCV10/13 period due to serotypes included in current and upcoming products. PCV13 is Pfizer’s Prevnar13/Prevenar13; PCV10 is GSK’s Synflorix. PCV13 results are modeled output. PCV10 results are a pooled distribution of 210 cases in Brazil and 43 cases in other PCV10 sites for <5 years of age and of 707 cases in Brazil and 181 cases in other PCV10 sites for ≥5 years of age. ST3 is illustrated separately in lighter purple in the bars corresponding to products that include ST3 due to the uncertain effectiveness against ST3 in current products [21,22,23]. ST6C is illustrated in grey above the bars where ST6A is included. Although ST6C is not included in PCV10 or PCV13, PCV13 offers cross-protection through ST6A [24]. ST6A also benefits from cross-protection with ST6B, included in both PCV10 and PCV13. Therefore, ST6A causes a very small fraction of disease in both settings and age groups, and it is not shown. Confidence intervals do not include ST6C, as this serotype is not included in PCV10/13.