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Modulator-binding site (M site) of the P-glycoprotein (P-gp) within the TM region, with superposition of the homology model and the crystal structure of the mouse P-gp bound with the QZ59-RRR inhibitor (PDB ID: 3G60). The inhibitor is represented as red sticks, the mouse P-gp is shown in salmon color, and the model in cyan; the cell membrane is represented by the blue (cytosolic side) and red (extracellular side) dots; the numeration is reported according to the human P-gp.
