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RAGE inhibition reduces autophagy in gemcitabine-treated tumors. Autophagy was assessed by measuring (A) the levels of p62 and (B) the levels of LC3-I and LC3-II, in tumor extracts from the different treatment groups by Western blot analysis (n = 4 in each group). The calculated ratios of LC3-II/LC3-I have been plotted. Representative blots are shown in A and B. * p < 0.05; ** p < 0.01; *** p < 0.001.
