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Anticoagulant activity of L. vannamei F4. (A) Activated partial thromboplastin time (aPTT) and (B) prothrombin time (PT) inhibitory response (mean % response, ± SD, n = 3) for heparin (open circle, dashed line) and L. vannamei F4 (closed circle, solid line). aPTT: heparin EC50 = 1.66 μg·mL–1; L. vannamei F4 EC50 = 27.91 μg·mL–1. PT: heparin EC50 = 19.53 μg·mL–1; L. vannamei F4 EC50 = 1276 μg·mL–1.
