Table 3.
Therapeutic ratio of L. vannamei F4 and F5 compared to heparin. The therapeutic ratio was calculated from the IC50 of BACE1 inhibitory activity measured by FRET:aPTT anticoagulant activity. GAG = glycosaminoglycan, PMIH = porcine mucosal intestinal heparin, aPTT = activated partial thromboplastin time, PT = prothrombin time.
| GAG | aPTT (μg·mL−1) | PT (μg·mL−1) | BACE1 Inhibitory Activity (μg·mL−1) | Therapeutic Ratio |
|---|---|---|---|---|
| PMIH | 1.66 | 19.53 | 2.43 | 0.68 |
| L.vannamei (F4) | 27.91 | 1276.00 | 4.61 | 6.10 |
| L.vannamei (F5) | 14.60 | 138.80 | 5.93 | 2.46 |