Figure 8.

Stimulatory effects of BRV on the activity of BK_Ca channels identified in mouse mHippoE-14 hippocampal neurons. In these experiments, cells were bathed in high K⁺ solution containing 1 µM of Ca²⁺; inside-out current recordings were performed, and channel activity was measured at a holding potential of +60 mV. (A) Representative channel current traces obtained in the control period (left, blue color) and after bath addition of 10 mM BRV (red color). Channel-opening event is denoted as an upward deflection (i.e., outward current); (B) Summary bar graph showing effects of BRV on the probability of channel opening during exposure to 10 or 30 mM of BRV (mean ± SEM; n = 8). * Significantly different from control (p < 0.05).