Table 1.
Minimum and maximum T2 values of 250 mM 13C-labelled biomolecules and pH-sensitivity of T2 in the physiological range pH 6.8–7.8 at 14.1 T.
| T2,max [s] (pH) | T2,min [s] (pH) | T2 [s] (pH 7.4) | Ratio T2,max/T2,min | Mean ΔT2 [s/0.1pH] (pH Range 6.8–7.8) | |
|---|---|---|---|---|---|
| [1-13C]acetate | 27.7 (10.90) | 2.1 (4.52) | 14.7 | 13.2 | 0.44 |
| [1-13C]alanine | 10.6 (12.45) | 0.6 (5.06) | 4.6 | 19.0 | 0.09 |
| [1,4-13C2]fumarate | 18.9 (12.91) | 3.0 (5.73) | 13.9 | 6.3 | 0.19 |
| [1-13C]lactate | 12.6 (1.03) | 0.7 (6.99) | 1.1 | 18.9 | −0.05 (pH 6.8–7)/ 0.08 (pH 7–7.8) |
| [1-13C]pyruvate | 18.7 (8.81) | 0.1 (11.69) | 13.9 | 208.1 | 0.95 |
| 13C-urea | 0.1 (7.79) | 0.1 (2.99) | 0.1 | 1.2 | <0.001 |
Note: For T2,max/min values, the corresponding pH is indicated in brackets. T2 values at pH 7.4 were calculated from the interpolation of data points in the close pH range. “Mean ΔT2” indicates the mean change in T2 in seconds per 0.1 pH step in the pH range 6.8–7.8, which is of interest for physiological conditions. All T2 values are rounded to the first digit after the decimal point.