Table 2.

Influence of concentration, salt concentration, temperature, and pH within common physiological and pathological variations on T₂ relaxation time constants of [1-¹³C]acetate at 7 T.

[1-13C]acetate	T2,ref [s]	T2,lower bound [s]	T2,upper bound [s]	Rel. Change Lower Bound [%]	Rel. Change Upper Bound [%]
Concentration	20.8	26.1	11.4	25.2	−45.4
Salt concentration	14.8	15.1	14.5	2.0	−1.8
Temperature	11.4	11.3	11.6	−1.6	1.5
pH	11.7	9.7	13.0	−16.9	11.2

Note: Parameter ranges and physiological reference values which are assumed to commonly apply to in vivo experiments in healthy subjects: concentration, reference 10 mM, lower bound 5 mM, upper bound 80 mM; salt concentration, reference 150 mM, lower bound 120 mM, upper bound 180 mM [40]; temperature, reference 37 °C, lower bound 35 °C, upper bound 39 °C; pH, reference 7.40, lower bound 6.8 [37], upper bound 7.8 [38].