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Receptor-mediated transcytosis. The ligand engages with the receptor at the luminal side of the BBB, followed by receptor-mediated endocytosis of the receptor-ligand complex into the EC, forming a clathrin-coated vesicle. The vesicle fuses with the endosome, after which the vesicle undergoes exocytosis, and the biomolecule is released on the abluminal side of the BBB.
