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. 2021 Apr 3;10(4):801. doi: 10.3390/cells10040801

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Naïve and effector T_reg subpopulations from RA patients showed significantly reduced CD25 expression. Expression of CD25 and Foxp3 was measured by flow cytometry in each CD4⁺ T cell subgroup from healthy controls (HC, n = 13) and RA patients (RA, n = 13). Subgroups were as follows: (A) I (CD25^intCD45RA⁺ cells), (B) II (CD25^hiCD45RA⁻ cells), (C) III (CD25^intCD45RA⁻ cells), (D) IV (CD25^lowCD45RA⁻ cells), (E) V (CD25⁻CD45RA⁻ cells), and (F) VI (CD25⁻CD45RA⁻ cells). Statistical differences were calculated by Mann–Whitney test.