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. 2021 Mar 31;9(4):733. doi: 10.3390/microorganisms9040733

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(A) Schematic drawing of the SARS-CoV-2 virus. Spike (S) and nucleocapsid (NC) proteins are highlighted. (B) Schematic drawing of the trimeric S-protein. (C) The domain structure of the S-protein is shown, and the three regions that were tested are depicted. All three versions contain the receptor binding domain (RBD). SP, signal peptide; NTD, N-terminal domain; S1, spike protein subunit 1; S2, spike protein subunit 2; FP, fusion peptide; HR1, heptad repeat 1 domain; HR2, heptad repeat 2 domain; TM, transmembrane domain; FD, foldon motif.