Table A2.
Studies reported to clinicaltrials.gov as “active, not recruiting” or “recruiting” on hyperpolarized carbon-13 MRI.
| Title | Condition | Trial Number | |
|---|---|---|---|
| 1 | Pilot Study of Safety and Toxicity of Acquiring Hyperpolarized Carbon-13 Imaging in Children With Brain Tumors | Pediatric brain tumors | NCT02947373 |
| 2 | Hyperpolarized Carbon-13 Imaging of Metastatic Prostate Cancer | Prostate cancer | NCT02844647 |
| 3 | Imaging of Traumatic Brain Injury Metabolism Using Hyperpolarized Carbon-13 Pyruvate | Traumatic brain injury | NCT03502967 |
| 4 | Metabolic Characteristics of Brain Tumors Using Hyperpolarized Carbon-13 Magnetic Resonance Spectroscopic Imaging (MRSI) | Brain tumor adult | NCT03067467 |
| 5 | Hyperpolarized Carbon 13-Based Metabolic Imaging to Detect Radiation-Induced Cardiotoxicity | Thoracic cancer/left sided breast cancer | NCT04044872 |
| 6 | Hyperpolarized Carbon-13 (13C) Pyruvate Imaging in Patients With Glioblastoma | Glioblastoma multiforme (GBM) | NCT04019002 |
| 7 | Hyperpolarized 13C Pyruvate MRI for Treatment Response Assessment in Patients With Locally Advanced or Metastatic Pancreatic Cancer | Pancreatic ductal adenocarcinoma | NCT04565327 |
| 8 | Feasibility of Acquiring Hyperpolarized Imaging in Patients With Primary CNS Lymphoma | Primary CNS lymphoma | NCT04656431 |
| 9 | Effect of Cardiotoxic Anticancer Chemotherapy on the Metabolism of [1-13C]Pyruvate in Cardiac Mitochondria | Breast neoplasms | NCT03685175 |
| 10 | Hyperpolarized Carbon C 13 Pyruvate Magnetic Resonance Spectroscopic Imaging in Predicting Treatment Response in Patients With Prostate Cancer | Prostate cancer | NCT03581500 |
| 11 | Hyperpolarized 13C Pyruvate MRI Scan in Predicting Tumor Aggressiveness in Patients With Localized Renal Tumor | Benign kidney cancer | NCT04258462 |
| 12 | Hyperpolarized Pyruvate (13C) MR Imaging in Monitoring Patients With Prostate Cancer on Active Surveillance | Prostate adenocarcinoma | NCT03933670 |
| 13 | Hyperpolarized Carbon C 13 Pyruvate in Diagnosing Glioma in Patients With Brain Tumors | Primary brain neoplasm | NCT03830151 |
| 14 | Serial MR Imaging and MR Spectroscopic Imaging for the Characterization of Lower Grade Glioma | Glioma | NCT04540107 |
| 15 | Hyperpolarized 13C MR Imaging of Lactate in Patients With Locally Advanced Cervical Cancer (LACC) Cervical Cancer | Uterine cervical neoplasms | NCT03129776 |
| 16 | Role of Hyperpolarized 13C-Pyruvate MR Spectroscopy in Patients With Intracranial Metastasis Treated With (SRS) | Brain metastases | NCT03324360 |
| 17 | Hyperpolarized Imaging in Diagnosing Participants With Glioma | Glioma | NCT03739411 |
| 18 | Metabolic Imaging of the Heart Using Hyperpolarized (13C) Pyruvate Injection | Hypertension/hypertrophy | NCT02648009 |
| 19 | Magnetic Resonance Imaging (MRI) With Hyperpolarized Pyruvate (13C) as Diagnostic Tool in Advanced Prostate Cancer | Prostate cancer | NCT04346225 |
| 20 | Imaging Oxidative Metabolism and Neurotransmitter Synthesis in the Human Brain | Brain cancer | NCT03849963 |
| 21 | Study to Evaluate the Feasibility of 13-C Pyruvate Imaging in Breast Cancer Patients Receiving Neoadjuvant Chemotherapy | Breast cancer | NCT03121989 |
| 22 | Development and Evaluation of a Quantitative HP MRI for Clinical Prostate Cancer Exam | Prostate adenocarcinoma | NCT04286386 |
| 23 | A Pilot Study of (MR) Imaging With Pyruvate (13C) to Detect High Grade Prostate Cancer | Prostate cancer | NCT02526368 |
| 24 | An Investigational Scan (hpMRI) for Monitoring Treatment Response in Patients With Thyroid Cancer Undergoing Radiation Therapy and/or Systemic Therapy | Thyroid gland carcinoma | NCT04589624 |
| 25 | Effect of Fatty Liver on TCA Cycle Flux and the Pentose Phosphate Pathway | Fatty liver | NCT03480594 |
| 26 | Hyperpolarized C-13 Pyruvate as a Biomarker in Patients With Advanced Solid Tumor Malignancies | Prostate cancer | NCT02913131 |
| 27 | Characterization of Hyperpolarized Pyruvate MRI Reproducibility | Malignant solid tumors | NCT02421380 |