Table A3.

Studies reported to EudraCT for clinical trials of hyperpolarized carbon-13 MRI.

	Title	Condition	EudraCT Number
1	Early detection of effects of chemotherapy in pancreatic cancer patients—a study using MR-hyperpolarization scanning based on hyperpolarized Pyruvate (13C) injection	Pancreatic cancer	2016-004491-22
2	MRI of neurometabolic impairment in ALS and TIA using hyperpolarized pyruvate	Amyotrophic lateral sclerosis	2020-000352-36
3	Clinical and pathophysiological aspects of visualization of metabolic flux in the failing human heart using hyperpolarized [1-13C]-pyruvate cardiac magnetic resonance	Chronic heart failure	2018-003533-15
4	MRI with hyperpolarised pyruvate in glioblastoma—a phase II study	Glioblastoma multiforme	2020-000310-15
5	Metabolic imaging of patients with mycosis fungoides using hyperpolarized 13C-Pyruvate magnetic resonance imaging—A feasibility study	Mycosis fungoides	2018-001656-35
6	A Dose-Ranging Pharmacodynamic Study to Evaluate the Effects of IMB-1018972 on Myocardial Energetics, Metabolism, and Function in Patients with Type 2 Diabetes	Diabetic cardiomyopathy	2020-003280-26