Table 1.

List of tumor suppressive microRNAs inactivating YAP/TAZ and their effect(s) on liver cancer.

MiRNA Name	Direct Target(s) † (Activator or Suppressor)	Effect(s) ‡	Disease Type	Ref.
miR-29c-3p	DNMT3B suppressor	LATS1 methylation ↓	HCC	[73]
miR-195	LATS2 activator	Apoptosis ↑	HCC	[74]
miR-497	YAP1 suppressor	Proliferation ↓, apoptosis ↑	HCC	[65]
miR-186	YAP1 suppressor	Proliferation, migration ↓	HCC	[59]
miR-590-5p	YAP1 suppressor	Chemoresistance ↓	HCC	[66]
miR-424-5p	YAP1 suppressor	Proliferation ↑, apoptosis ↓	HCC	[64]
miR-506	YAP1 suppressor	Proliferation ↓	HCC	[61]
miR-132	YAP1 suppressor	Apoptosis ↑	HCC	[62]
miR-375	YAP1 and CTGF suppressor	Growth, invasion ↓	FLC	[58]
	YAP1/2 suppressor	Proliferation, invasion ↓	HCC	[57]
miR-125b	TAZ suppressor	Migration, invasion ↓	HCC	[71]
miR-9-3p	TAZ suppressor	Proliferation ↓	HCC	[70]
miR-223	TAZ suppressor	Neutrophil activation(proinflammatory mediators) ↓	NASH, HCC	[72]
miR-338-3p	TAZ suppressor	preS2 expression ↓	HCC (HBV derived)	[69]

Abbreviation: miR, microRNA; HCC, hepatocellular carcinoma; FLC, fibrolamellar carcinoma; NASH, nonalcoholic steatohepatitis; HBV, hepatitis B virus. ^† All direct targets were confirmed by luciferase reporter assay. ^‡ ↑ indicates the promotion, ↓ indicates the suppression.