Table 1.
The predicted biological activities of 1, 25-di(OH)-vitamin D.
| Vitamin D2 | Vitamin D3 | Vitamin D4/D7 ∗ | Vitamin D5 | Vitamin D6 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Activity | Pa 1 | Pi 2 | Pa | Pi | Pa | Pi | Pa | Pi | Pa | Pi |
| Anti-osteoporotic | 0.982 a | 0.003 | 0.973 b | 0.003 | 0.969 | 0.003 | 0.965 | 0.003 | 0.970 | 0.003 |
| Bone diseases treatment | 0.981 a | 0.003 | 0.976 b | 0.003 | 0.968 | 0.003 | 0.966 | 0.003 | 0.966 | 0.003 |
| Vitamin | 0.977 b | 0.000 | 0.975 | 0.000 | 0.936 | 0.000 | 0.978 a | 0.000 | 0.976 | 0.000 |
| Hyperparathyroidism treatment | 0.946 a | 0.000 | 0.933 b | 0.000 | 0.883 | 0.000 | 0.882 | 0.000 | 0.901 | 0.000 |
| Calcium regulator | 0.902 a | 0.001 | 0.876 | 0.002 | 0.869 | 0.002 | 0.870 | 0.002 | 0.880 b | 0.001 |
| Vitamin D-like | 0.869 a | 0.000 | 0.757 | 0.000 | 0.578 | 0.000 | 0.791 | 0.000 | 0.844 b | 0.000 |
| Vitamin D receptor agonist | 0.816 a | 0.000 | 0.693 | 0.000 | 0.680 | 0.000 | 0.686 | 0.000 | 0.738 b | 0.000 |
| Bone formation stimulant | 0.578 | 0.004 | 0.598 | 0.004 | 0.628 b | 0.003 | 0.634 a | 0.003 | 0.627 | 0.003 |
1,2 Pa (probability to be active) and Pi (probability to be inactive) values were estimated by PASS (Prediction of Activity Spectra for Substances) online. The closer the Pa value is to 1, the higher the activity. The larger the Pi value, the more inactive it is. ∗ These isomers cannot be distinguished by PASS. a: Highest activity among vitamins D. b: Second highest activity among vitamins D. a,b: both judged by both Pa value and Pi value.