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. 2021 Apr 23;3:11. doi: 10.1186/s42238-021-00067-z

Table 1.

Results from cell-based assays with HU-331

Cell line Key findings/resultsa Reference
Raji (Burkitt’s lymphoma)

IC50 ~0.61 μM

HU-331-mediated cell death is not apoptotic

Kogan et al. (2004)

Kogan et al. 2007b

Jurkat (T-cell lymphoma)

IC50 ~1.2 μM

HU-331-mediated cell death is not apoptotic

Kogan et al. (2004)

Kogan et al. (2007b)

SNB-19 (glioblastoma) IC50 ~38 μM Kogan et al. (2004)
MCF-7 (breast cancer) IC50 ~9.5 μM Kogan et al. (2004)
DU-145 (prostate cancer)

IC50 ~38 μM

IC50 9.2 μM

Kogan et al. (2004)

Waugh et al. (2020)

NCI-H-226 (lung cancer) IC50 <38 μM Kogan et al. (2004)
HT-29 (colon cancer)

IC50 ~9.5 μM

HU-331-mediated cell death is not apoptotic

Kogan et al. (2004)

Kogan et al. (2007b)

BAEC (bovine aortic endothelial)

IC50 <1.2 μM

HU-331-mediated cell death is apoptotic

Kogan et al. (2006)
HUVEC (human umbilical vein endothelial)

HU-331-mediated cell death is apoptotic

Changes in gene expression observed

Kogan et al. (2006)
U-87 (human glioblastoma) IC50 9.51 μM Macieja et al. (2019)

aIC50 values either reported directly or deduced from reported data