Table 1.
Results from cell-based assays with HU-331
Cell line | Key findings/resultsa | Reference |
---|---|---|
Raji (Burkitt’s lymphoma) |
IC50 ~0.61 μM HU-331-mediated cell death is not apoptotic |
Kogan et al. (2004) Kogan et al. 2007b |
Jurkat (T-cell lymphoma) |
IC50 ~1.2 μM HU-331-mediated cell death is not apoptotic |
Kogan et al. (2004) Kogan et al. (2007b) |
SNB-19 (glioblastoma) | IC50 ~38 μM | Kogan et al. (2004) |
MCF-7 (breast cancer) | IC50 ~9.5 μM | Kogan et al. (2004) |
DU-145 (prostate cancer) |
IC50 ~38 μM IC50 9.2 μM |
Kogan et al. (2004) Waugh et al. (2020) |
NCI-H-226 (lung cancer) | IC50 <38 μM | Kogan et al. (2004) |
HT-29 (colon cancer) |
IC50 ~9.5 μM HU-331-mediated cell death is not apoptotic |
Kogan et al. (2004) Kogan et al. (2007b) |
BAEC (bovine aortic endothelial) |
IC50 <1.2 μM HU-331-mediated cell death is apoptotic |
Kogan et al. (2006) |
HUVEC (human umbilical vein endothelial) |
HU-331-mediated cell death is apoptotic Changes in gene expression observed |
Kogan et al. (2006) |
U-87 (human glioblastoma) | IC50 9.51 μM | Macieja et al. (2019) |
aIC50 values either reported directly or deduced from reported data