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Multidirectional impact of ultraviolet radiation on skin aging. (UVR, ultraviolet radiation; MMPs, matrix metalloproteinases; ROS, reactive oxygen species; NF-ĸβ, nuclear factor kappa-light-chain-enhancer of activated B cells; FOXO3α, Forkhead Box O3 alpha; NER, nucleotide excision repair system; SIRT1, sirtuin 1).
