Table 4.

Summary of the studies in penile cancer that evaluated the expression (immunohistochemistry or immunofluorescence) of the same proteins presented in our RPPA (reverse-phase protein arrays) analysis.

Protein	Number of Cases	Expression	Reference	Cell
				2	3	4	5	6
Akt1	148	↑	Stankiewicz et al., 2011 [36]	↓	↑	-	↑	-
pAkt	112	↑	Chaux et al., 2014 [37]	-	↑	-	↑	↓
pAkt	148	↑	Stankiewicz et al., 2011 [36]	-	↑	-	↑	↓
pAkt	57	↑	Azizi et al., 2019 [38]	-	↑	-	↑	↓
ARID1A	112	↑	Faraj et al., 2015 [39]	↑	↑	↓	↑	↑
c-MET	92	↑	Gunia et al., 2013 [40]	-	-	-	-	-
c-MYC	141	↓	Arya et al., 2015 [41]	-	-	-	-	↓
cyclinD1	141	↓	Arya et al., 2015 [41]	-	-	-	-	-
EGFR	139	↑	Silva Amancio et al., 2017 [42]	↑	-	-	↑	-
EGFR	52	↑	Dorff et al., 2016 [43]	↑	-	-	↑	-
EI2F	13	↑	Fenner et al., 2018 [20]	↑	↑	-	↑	-
eIF4E	67	↑	Ferrandiz-Pulido et al., 2013 [44]	↑	↑	-	-	↓
peIF4E	67	↑	Ferrandiz-Pulido et al., 2013 [44]	-	-	-	-	-
HER2	148	↑	Stankiewicz et al., 2011 [36]	↑	↑	-	-	-
HER3	148	↑	Stankiewicz et al., 2011 [36]	↑	↑	-	-	-
HER4	148	↑	Stankiewicz et al., 2011 [36]	-	-	-	-	-
p16	58	↑	Steinestel et al., 2015 [45]	↓	↓	-	↓	↓
p16	202	↑	Cubilla et al., 2011 [46]	↓	↓	-	↓	↓
p16	119	↑	Tang et al., 2015 [47]	↓	↓	-	↓	↓
p16	123	↑	Mannweiler et al., 2013 [48]	↓	↓	-	↓	↓
p4E-BP1	67	↑	Ferrandiz-Pulido et al., 2013 [44]	↑	↑	-	-	-
p53	123	↑	Mannweiler et al., 2013 [48]	-	-	-	-	-
p53	110	↑	Gunia et al., 2013 [49]	-	-	-	-	-
p53	297	↑	Rocha et al., 2012 [50]	-	-	-	-	-
PDL1	116	↑	Deng et al., 2017 [51]	-	↑	-	-	-
PDL1	37	↑	Udager et al., 2016 [52]	-	↑	-	-	-
PDL1	52	↑	Cocks et al., 2017 [53]	-	↑	-	-	-
PDL1	213	↑	Ottenhof et al., 2017 [54]	-	↑	-	-	-
pmTOR	67	↑	Ferrandiz-Pulido et al., 2013 [44]	↑	-	-	-	↑
pmTOR	112	↑	Chaux et al., 2014 [37]	↑	-	-	-	↑
PTEN	112	↓	Chaux et al., 2014 [37]	-	-	-	-	-
PTEN	148	↓	Stankiewicz et al., 2011 [36]	↓	↑	-	↓	↓
PTEN	57	↓	Azizi et al., 2019 [38]	↓	↑	-	↓	↓
pS6	57	↑	Azizi et al., 2019 [38]	↑	-	-	↑	-
SOD2	125	↑	Termini et al., 2015 [55]	↑	↑	↑	↑	-

↑: increased expression; ↓: decreased expression; -: no change in expression levels.