Table 1.
Association between PPM1D expression levels and clinical/molecular data across public datasets.
| Variable | GSE6891 [48] (n = 499) | GSE13159 [49] (n = 458) | TCGA [50] (n = 178) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| PPM1D Median | n (%) | p-Value | PPM1D Median | n (%) | p-Value | PPM1D Median (Min–Max) | n (%) | p-Value | |
| (Min–Max) | (Min–Max) | ||||||||
| Age ‡ | |||||||||
| <60-years | 151.6 (83.9–393.3) | 417 (84.8) | 0.03 | NA | NA | NA | 25.6 (15.1–46.7) | 92 (51.7) | 0.004 |
| ≥60-years | 146.7 (94.5–234.4) | 75 (15.2) | 22.6 (14.2–39.4) | 86 (48.3) | |||||
| NA = 7 | |||||||||
| Cytogenetic group ‡ | |||||||||
| t(8;21) | 169.8 (89.9–318.9) | 38 (9.0) | 0.185 | 106.2 (32.6–309.9) | 35 (7.6) | <0.001 | 25.7 (22.3–31.7) | 7 (4.2) | 0.031 |
| inv(16)/t(16;16) | 156.3 (95.8–319.7) | 42 (10.0) | 73.2 (41.4–134.6) | 27 (5.9) | 27.6 (20.5–38.7) | 11 (6.6) | |||
| NK | 147.5 (83.9–371.3) | 171 (40.5) | NA | 0 | 23.5 (15.1–46.7) | 96 (57.8) | |||
| CK | 146.4 (97.9–259.7) | 34 (8.1) | 99.3 (31.5–279.4) | 45 (9.8) | 24.4 (15.2–39.0) | 21 (12.7) | |||
| KMT2A-r | 139.6 (94.3–256.3) | 17 (4.0) | 72.2 (28.2–233.4) | 29 (6.3) | 29.1 (18.3–46.1) | 10 (6.0) | |||
| Other | 143.1 (84.1–393.3) | 120 (28.4) | NA | 0 | 21.9 (14.2–29.5) | 21 (12.7) | |||
| Normal/Other * | 72.2 (23.4–263.2) | 322 (21.8) | |||||||
| NA = 77 | NA = 12 | ||||||||
| FLT3-ITD ‡ | |||||||||
| FLT3-ITD+ | 146.1 (87.6–371.3) | 134 (26.9) | 0.017 | NA | NA | NA | 24.2 (14.2–46.7) | 32 (18.4) | 0.87 |
| FLT3-ITD− | 152.2 (83.9–393.3) | 365 (73.1) | 23.2 (15.2–39.0) | 143 (81.7) | |||||
| NA = 3 | |||||||||
| NPM1 status ‡ | |||||||||
| NPM1-mut | 143.1 (83.9–371.3) | 159 (39.9) | 0.002 | NA | NA | NA | 23.7 (16.1–46.7) | 53 (30.3) | 0.69 |
| NPM1-wt | 155.8 (84.1–393.3) | 340 (68.1) | 24.0 (14.2–46.1) | 122 (69.7) | |||||
| NA = 3 | |||||||||
‡ The sum does not add up to the total due to missing values. * “NK” and “other” cytogenetic subgroups were not distinguished in GSE13159. CK: complex karyotype; ITD: internal tandem duplication; KMT2A-r: KMT2A-rearranged; min-max: minimum-to-maximum value; mut: mutated; NA: not available; NK: normal karyotype; wt: wildtype.