Table 2.

Most significant enriched pathways in MV-4-11 cells upon drug treatment.

Pathway Name	NES	FDR	Reatment Comparison
Hallmark of p53 Pathway	2.31	≤0.001	Nut3a+WIP1i vs. DMSO
	2.13	≤0.001	Nut3a vs. DMSO
	1.49	0.029	WIP1i vs. DMSO
Hallmark of Protein Secretion	1.98	≤0.001	Nut3a+WIP1i vs. DMSO
	2.24	≤0.001	Nut3a vs. DMSO
	1.73	0.005	WIP1i vs. DMSO
Hallmark of Oxidative Phosphorylation	1.87	0.001	Nut3a+WIP1i vs. DMSO
	1.94	≤0.001	Nut3a vs. DMSO
	2.31	0.005	WIP1i vs. DMSO
Hallmark of Apoptosis	1.70	0.009	Nut3a+WIP1i vs. DMSO
	1.70	0.003	Nut3a vs. DMSO
	1.52	0.024	WIP1i vs. DMSO
Hallmark of mTORC1 Signaling	1.75	0.002	Nut3a vs. DMSO
	1.88	0.003	WIP1i vs. DMSO
Hallmark of Fatty Acid Metabolism	1.75	0.002	Nut3a vs. DMSO
	1.62	0.010	WIP1i vs. DMSO
Hallmark of DNA Repair	1.58	0.014	Nut3a vs. DMSO
	1.63	0.011	WIP1i vs. DMSO
Hallmark of Peroxisome	1.52	0.024	Nut3a vs. DMSO
	1.80	0.005	WIP1i vs. DMSO
Hallmark of TNFA Signaling Via NFKB	1.57	0.021	Nut3a+WIP1i vs. DMSO
Hallmark of Interferon Gamma Response	1.53	0.022	Nut3a+WIP1i vs. DMSO
Hallmark of Interferon Alpha Response	1.54	0.023	Nut3a+WIP1i vs. DMSO
Hallmark of PI3K AKT mTOR Signaling	1.73	0.002	Nut3a vs. DMSO
Positive Regulation Of Cysteine Type Endopeptidase Activity Involved In Apoptotic Signaling Pathway	2.21	0.030	Nut3a vs. DMSO
Oligosaccharide-Lipid Intermediate Biosynthetic Process	2.19	0.013	Nut3a vs. DMSO
Hallmark of MYC Targets_V2	1.72	0.006	WIP1i vs. DMSO
Hallmark of Unfolded Protein Response	1.67	0.008	WIP1i vs. DMSO
Hallmark of MYC Targets_V1	1.62	0.011	WIP1i vs. DMSO

FDR: false discovery rate; NES: normalized enrichment score.