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. 2021 Apr 6;10(4):816. doi: 10.3390/cells10040816

Figure 6.

Figure 6

Effects of signal transduction inhibitors on the growth of MIA-PaCa-2 + WT-GSK-3β, MIA-PaCa-2 + KD-GSK-3β and MIA-PaCa-2 + pLXSN cells. The effects of the pan EGFR ARRY-543 inhibitor (Panel (A)), the KRAS ARS-1620 inhibitor (Panel (B)), the MEK1 PD0325901 inhibitor (Panel (C)), and the mTORC1 blocker rapamycin (Panel (D)) on MIA-PaCa-2 + WT-GSK-3β (solid red boxes), MIA-PaCa-2 + KD-GSK-3β (solid blue triangles) and, MIA-PaCa-2 + pLXSN Cells (solid green circles) were examined by MTT analysis. The MIA-PaCa-2 + WT-GSK-3β, MIA-PaCa-2 + KD-GSK-3β and MIA-PaCa-2 + pLXSN cells in each panel were all examined at the same time period. These experiments were repeated 4 times and similar results were obtained. Statistical analyses were performed via the Student’s T test on the means and standard deviations of various treatment groups. *** p < 0.0001, and ** p < 0.005.