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. 2021 Apr 6;10(4):823. doi: 10.3390/cells10040823

Figure 2.

Figure 2

C. minuta DSM33407 prevents accumulation of visceral fat mass and hyperglycemia in a DIO mouse model (n = 10). (A) Growth curve of animals fed a normal chow (NC) or high-fat diet (HFD) and treated by oral gavage with a solution of vehicle (Veh) or C. minuta DSM33407 (DSM33407) for 4 weeks. (B) Associated feed efficiency over the 4-week treatment period. (C) Fasted glycemia was measured at baseline and at the end of the 4-week treatment period. (D) Representative pictures of mesenteric white adipose tissue hematoxylin and eosin staining after 40 days of treatment (scale bar: 100 mm) and associated adipocyte atrophy scores (E). Plasma leptin (F), resistin (G), and changes in fat mass (H) were measured after 12 weeks of treatment. Key: BW, Body Weight; FE, Feed Efficiency. Statistics: Two-way repeated measures ANOVA followed by two-stage linear step-up procedure of Benjamini, Krieger, and Yekutieli multiple comparisons (A–C), Mann–Whitney U test (E), one-way ANOVA followed by Tukey’s multiple comparisons (F,G); * p < 0.05, ** p < 0.01, *** p < 0.001.