Table 1.
LTR elements that are significantly differentially expressed (p-value < 0.05 and |fold change| ≥ 2) in glioblastoma multiforme (GBM) tissues, cell cultures, and normal brain (NB). The superfamily, CPM (counts per million), and fold change of the differentially expressed LTR elements in GBM and normal brain samples are presented.
| LTR Elements | Superfamily | NB Mean CPM | GBM Mean CPM | Fold Changes GBM vs. NB |
|---|---|---|---|---|
| MLT1M-int_LTR_ERVL-MaLR | ERV3 | 0 | 0.03 | 13.85 |
| LTR21A_LTR_ERV1 | ERV1 | 48.57 | 249.19 | 5.13 |
| LTR06_LTR_ERV1 | ERV1 | 9.29 | 36.37 | 3.91 |
| LTR39_LTR_ERV1 | ERV1 | 281.42 | 947.75 | 3.37 |
| MER57F_LTR_ERV1 | ERV1 | 44.07 | 145.12 | 3.29 |
| LTR25-int_LTR_ERV1 | ERV1 | 98.72 | 324.11 | 3.28 |
| LTR47A2_LTR_ERVL | ERV3 | 26.76 | 87.46 | 3.27 |
| LTR45_LTR_ERV1 | ERV1 | 12.9 | 41.61 | 3.23 |
| LTR25_LTR_ERV1 | ERV1 | 53.83 | 161.48 | 3 |
| LTR58_LTR_ERV1 | ERV1 | 13.2 | 39.2 | 2.97 |
| LTR10B1_LTR_ERV1 | ERV1 | 31.4 | 92.43 | 2.94 |
| MamGypLTR1b_LTR_Gypsy | Gypsy | 106.56 | 305.69 | 2.87 |
| LTR46-int_LTR_ERV1 | ERV1 | 70.41 | 199.2 | 2.83 |
| LTR5_LTR_ERVK | ERV2 | 32.82 | 85.7 | 2.61 |
| LTR57_LTR_ERVL | ERV3 | 49.21 | 127.45 | 2.59 |
| MER65C_LTR_ERV1 | ERV1 | 60.88 | 156.72 | 2.57 |
| LTR4_LTR_ERV1 | ERV1 | 24.56 | 61.49 | 2.5 |
| LTR6B_LTR_ERV1 | ERV1 | 42.14 | 103.63 | 2.46 |
| MST-int LTR ERVL-MaLR | ERV3 | 132.56 | 320 | 2.41 |
| LTR6A_LTR_ERV1 | ERV1 | 137.45 | 325.28 | 2.37 |
| LTR76_LTR_ERV1 | ERV1 | 60.3 | 141.55 | 2.35 |
| HERV3-int_LTR_ERV1 | ERV1 | 118.4 | 275.59 | 2.33 |
| LTR26_LTR_ERV1 | ERV1 | 48.93 | 112.36 | 2.3 |
| HERVFH21-int_LTR_ERV1 | ERV1 | 22.23 | 50.74 | 2.28 |
| HERV1_LTRd_LTR_ERV1 | ERV1 | 6.46 | 14.7 | 2.28 |
| LTR3_LTR_ERVK | ERV2 | 65.17 | 145.43 | 2.23 |
| MER9B_LTR_ERVK | ERV2 | 16.12 | 35.17 | 2.18 |
| LTR23_LTR_ERV1 | ERV1 | 61.05 | 132.71 | 2.17 |
| MER92B_LTR_ERV1 | ERV1 | 96.38 | 209 | 2.17 |
| LTR30_LTR_ERV1 | ERV1 | 29.1 | 62.58 | 2.15 |
| MER51D_LTR_ERV1 | ERV1 | 11.86 | 25.37 | 2.14 |
| LTR35_LTR_ERV1 | ERV1 | 25.63 | 54.69 | 2.13 |
| HERVFH19-int_LTR_ERV1 | ERV1 | 10.32 | 21.85 | 2.12 |
| HERVS71-int_LTR_ERV1 | ERV1 | 122.04 | 256.2 | 2.1 |
| MER9a3_LTR_ERVK | ERV2 | 100.84 | 210.7 | 2.09 |
| MER4B-int_LTR_ERV1 | ERV1 | 105.81 | 221.07 | 2.09 |
| MER4-int_LTR_ERV1 | ERV1 | 317.48 | 656.31 | 2.07 |
| HERV15-int_LTR_ERV1 | ERV1 | 24.28 | 49.96 | 2.06 |
| MER57E3_LTR_ERV1 | ERV1 | 31.62 | 64.73 | 2.05 |
| LTR108a_Mam_LTR_ERVL | ERV3 | 25.92 | 52.95 | 2.04 |
| MER34A1_LTR_ERV1 | ERV1 | 77.33 | 157.29 | 2.03 |
| HERVK11D-int_LTR_ERVK | ERV2 | 6.01 | 12.2 | 2.03 |
| MLT1F1-int_LTR_ERVL-MaLR | ERV3 | 40.73 | 82.56 | 2.03 |
| LTR70_LTR_ERV1 | ERV1 | 37.51 | 75.05 | 2 |
| LTR1E_LTR_ERV1 | ERV1 | 45.06 | 21.22 | −2.12 |
| HERV-Fc1_LTR2_LTR_ERV1 | ERV1 | 0.34 | 0.16 | −2.16 |
| MER11B_LTR_ERVK | ERV2 | 25,765.36 | 3311.14 | −7.78 |