Table 2.

Cross-protective immune responses elicited by LAIVs.

Immune Responses	Mechanism of Attenuation
HA stalk antibodies	Viral neutralization Antibody effector functions
NA antibodies	Neuraminidase inhibition Antibody effector functions
M2e antibodies	Viral neutralization Antibody effector functions
Antibodies to internal proteins	Antibody effector functions
T cell response	Cytotoxicity to virus-infected cells
Mucosal immunity	Viral neutralization Non-neutralizing activity
Innate immunity	Non-specific effects