. 2021 Apr 7;13(4):505. doi: 10.3390/pharmaceutics13040505

Table 3.

Parameters of each model applied to the selected samples to study the mechanism of Curcumin release.

Model	Parameter	Formulation
Model	Parameter	LVM	CT4LVM	H4LVM
Zero-order ¹ Q_t = Q₀ + K₀ ∙ t	K₀	0.462	0.294	0.425
	Q₀	18.378	22.254	16.071
	R²_adj	0.730	0.678	0.697
First-order ¹ ln Q_t = ln Q₀ + K_1th ∙ t	K_1th	0.005	0.003	0.005
	Q₀	31.008	32.322	28.660
	R²_adj	0.533	0.503	0.468
Higuchi ¹ Q_t = Q₀ + K_H ∙ t^1/2	K_H	7.417	6.199	6.748
	Q₀	0	0	0
	R²_adj	0.896	0.887	0.864
Korsmeyer-Peppas ¹ Q_t = Q₀+ K_KP ∙ tⁿ	K_KP	6.370	7.533	5.555
	Q₀	0	0	0
	n	0.532	0.461	0.541
	R²_adj	0.884	0.878	0.846

¹ where “K” is the kinetic constant, “Q_t” is the cumulative amount of drug released at time “t”, and “Q₀” is the initial amount of drug; for Korsmeyer-Peppas equation “Q₀” is the amount of the drug released after infinite time [52,53,54].