Table 3.
Key secondary outcomes: anxiety (STAI I and STAI II), depression (MADRS and BDI), and plasma redox status parameters (GSH and TBARS).
| Outcome | CG Group Mean (SD) (n = 29) |
PMI Group Mean (SD) (n = 26) |
F (p-Value) |
|---|---|---|---|
| STAI I | |||
| T0 | 43.4 (12.1) | 41.8 (10.7) | Time effect: 5.07 (0.01) |
| T1 | 39.9 (11.3) | 41.7 (9.2) | Group effect: 1.91 (0.173) |
| T2 | 41.9 (9.0) | 33.0 (8.1) | Interaction group × time: 7.87 (0.001) |
| STAI II | |||
| T0 | 42.3 (10.7) | 41.0 (9.3) | Time effect: 7.46 (0.001) |
| T1 | 40.4 (11.0) | 39.3 (9.7) | Group effect: 5.52 (0.023) |
| T2 | 41.6 (10.3) | 29.4 (10.3) | Interaction group × time: 7.71 (0.0012) |
| MADRS | |||
| T0 | 10.2 (8.2) | 8.6 (5.7) | Time effect: 5.39 (0.0074) |
| T1 | 7.4 (6.5) | 6.4 (3.5) | Group effect: 3.27 (0.076) |
| T2 | 8.1 (5.4) | 4.5 (3.4) | Interaction group × time: 2.07 (0.136) |
| BDI | |||
| T0 | 12.2 (10.7) | 10.2 (6.6) | Time effect: 3.39 (0.041) |
| T1 | 9.5 (6.4) | 6.6 (5.5) | Group effect: 4.93 (0.031) |
| T2 | 11.0 (5.8) | 5.9 (6.9) | Interaction group × time: 1.37 (0.263) |
| GSH (µM) | |||
| T0 | 3.6 (1.7) | 4.0 (1.6) | Time effect: 13.77 (<0.0001) |
| T1 | 4.6 (2.7) | 4.8 (2.0) | Group effect: 1.52 (0.223) |
| T2 | 4.8 (2.0) | 6.0 (3.8) | Interaction group × time: 0.62 (0.542) |
| TBARS (µM) | |||
| T0 | 1.9 (1.2) | 2.2 (1.7) | Time effect: 5.83 (0.005) |
| T1 | 1.8 (0.9) | 1.5 (0.8) | Group effect: 0.08 (0.782) |
| T2 | 1.4 (0.7) | 1.2 (0.4) | Interaction group × time: 0.94 (0.395) |
GSH: glutathione; TBARS: thiobarbituric acid reactive substances. Abbreviations are as in Table 2.