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. 2021 Apr 7;13(8):1756. doi: 10.3390/cancers13081756

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Impact of pH on 2-HG-lactonization in cells. IDH1/2 mutant cells were cultured under acidified conditions to investigate the impact of pH on 2-HG lactonization. (A,B) Extra- and intracellular concentrations of 2-HG and 2-HG-lactone after 6 h for HT1080 cells; (C,D) extra- and intracellular concentrations of 2-HG and 2-HG-lactone after 6 h for HCT116 IDH2-R140Q. 2-HG-lactone was below the LLOQ in cell extracts. (n = 2–3; error bars indicate SD; and percentages represent amounts of 2-HG-lactone relative to the sum of 2-HG and 2-HG-lactone).