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. 2021 Apr 7;22(8):3817. doi: 10.3390/ijms22083817

Table 3.

Antiproliferative activity of cisplatin and platinum(IV) prodrugs 2 and 3 on HCT-116 (colorectal carcinoma), OVCAR3 (ovarian cancer), MDA-MB-231 (triple negative breast cancer), and 1483 HNSCC (head and neck squamous cell carcinoma) cell lines. The ability of cells to express cyclooxygenase-2 (COX-2) is indicated by “−” (non-expressing), “+” (expressing), “++” (strongly expressing).

Compound/Cell Line IC50, µM
HCT-116 OVCAR3 MDA-MB-231 1483 HNSCC
COX-2 expression + + ++
Cisplatin 12 2.07 20 2
2 1.1 2.2 1.65 0.69
3 0.065 0.13 0.05 0.045