Table 4.

Antiproliferative activity of oxaliplatin-based platinum(IV) prodrugs 4 and 5 and cisplatin on HCT-116 (colorectal carcinoma) and MDA-MB-231 (triple negative breast adenocarcinoma) cell lines. The ability of cells to express cyclooxygenase-2 (COX-2) is indicated by “−” (non-expressing), “+” (expressing).

Compound/Cell Line	IC50, µM
	HCT-116	MDA-MB-231
COX-2 expression	-	+
Cisplatin	12	20
4	1.3	0.55
5	0.31	0.33