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Cellular uptake in PC-3 (prostate carcinoma), SGC7901 (gastric cancer), SGC7901/CDDP (cisplatin-resistant gastric cancer), and LO-2 (normal liver) cell lines preincubated with prodrugs 25, 26, and cisplatin after 12 hours of incubation (ng/106 cells).
| Compound/Cell Line | Cellular Uptake, ng/106 Cells | |||
|---|---|---|---|---|
| PC-3 | SGC7901 | SGC7901/CDDP | LO-2 | |
| Cisplatin | 133 | 120 | 28 | 141 |
| 25 | 276 | 451 | 269 | 372 |
| 26 | 839 | 790 | 757 | 403 |
