Table 15.

Antiproliferative activity of cisplatin and platinum(IV) prodrugs 27–32 on HCT-15 (human colon carcinoma), BCAP (thyroid cancer), PSN-1 (pancreatic cancer), LoVo (colon cancer), 2008 (ovarian adenocarcinoma), and C13* (cisplatin-resistant ovarian adenocarcinoma) cell lines. Resistance factor (RF) = IC₅₀ (C13*)/IC₅₀ (2008).

Class	IC50, µM
	Compound/Cell Line	HCT-15	BCPAP	PSN-1	LoVo	2008	C13*	RF
PDKi, COXi	27	1.03 ± 0.25	0.06 ± 0.005	0.06 ± 0.008	0.755 ± 0.06	0.61 ± 0.19	1.66 ± 0.09	2.7
	28	0.65 ± 0.17	0.14 ± 0.04	0.08 ± 0.01	0.285 ± 0.02	0.32 ± 0.09	0.97 ± 0.22	3
HDACi, COXi	29	1.86 ± 0.41	0.06 ± 0.004	0.09 ± 0.02	0.055 ± 0.01	0.29 ± 0.11	0.43 ± 0.12	1.5
	30	4.98 ± 1.25	0.08 ± 0.01	0.92 ± 0.2	0.211 ± 0.08	0.89 ± 0.19	1.65 ± 0.11	1.9
	31	3.98 ± 0.89	0.68 ± 0.08	0.07 ± 0.01	0.034 ± 0.03	1.35 ± 0.29	1.61 ± 0.42	1.2
	32	4.51 ± 0.85	0.01 ± 0.003	0.13 ± 0.04	0.97 ± 0.08	0.69 ± 0.08	0.77 ± 0.04	1.1
Reference	Cisplatin	15.28 ± 2.63	7.38 ± 1.53	18.25 ± 3.11	9.15 ± 2.07	2.22 ± 1.02	22.52 ± 3.15	10.10
	Oxaliplatin	1.15 ± 0.43	4.37 ± 1.07	8.25 ± 3.42	1.01 ± 0.34	1.53 ± 0.88	3.06 ± 1.00	2.00