Table 16.

Antiproliferative activity of platinum(IV) prodrugs 27–32 on HEK293 (non-cancerous embryotic kidney) cell line. Selectivity index (SI) = IC₅₀ (normal cell line)/IC₅₀ (tumor cell line).

			Selectivity Index (SI)
Class	Compound/Cell Line	IC50, µM HEK293	PSN-1	BCPAP	LoVo
PDKi, COXi	27	0.09 ± 0.02	1.5	1.5	0.1
	28	0.07 ± 0.03	0.9	0.5	0.2
HDACi, COXi	29	0.11 ± 0.01	1.2	1.8	2
	30	0.13 ± 0.03	0.1	1.6	0.6
	31	0.47 ± 0.08	6.7	0.7	13.8
	32	0.59 ± 0.21	4.5	59	0.6
Reference	Cisplatin	19.62 ± 2.33