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. 2021 Apr 7;10(4):830. doi: 10.3390/cells10040830

Figure 4.

Figure 4

KLF4 aids autophagic cell death in response to glucose starvation in an N-acetylcysteine (NAC)-independent manner. (A) MEF morphology. (B) WT MEFs die at a greater rate as compared to Klf4-null MEFs in response to glucose starvation. (C,D) KLF4 induces autophagic cell death in MEFs in response to starvation, independent of reactive oxygen species (ROS). Each assay was performed using four biological replicates. Error bars represent standard error of the mean. Significance was determined by Student’s t-test (* p < 0.05).