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KLF4′s role in responding to glucose starvation. Reduced glucose intake increases ROS as well as KLF4. KLF4 protects the cell by inhibiting ROS and inducing autophagic cell death. Furthermore, KLF4 responds to reduced glucose intake by facilitating GLUT1 localization to the cellular membrane. Additionally, KLF4 increases PKM2 to favor oxidative phosphorylation and increases MCT4 to export lactate out the cell. Created using BioRender.
