Table 1.

Patient characteristics. The p-values related to age are calculated by T-test (columns 5 and 6, marked in italics). The other group comparisons of columns 5 and 6 were performed with two-sided Fisher’s exact test. Values statistically significant at the 5% significance level are marked with *. Abbreviations: − = negative, + = positive, chemo = chemotherapy, IQR = interquartile range, RT = radiotherapy.

Patient Characteristics		1	2	3	4	5	6
		Total	HPV+ Nonsmokers	HPV+ Smokers	HPV− Patients	p-Values HPV+ vs. HPV− (n = 57 vs. n = 34)	p-Values Smokers vs. Nonsmokers (n = 69 vs. n = 22)
		n = 91	n = 20	n = 37	n = 34
Age at diagnosis of index tumor	Median (y)	59.54	58.2	58.7	57.6	0.483	0.646
	IQR	52.7–65.6	52.8–66.7	51.0–67.3	53.8–65.1
Sex
male	n (%)	68 (74.7%)	14 (70%)	28 (75.7%)	26 (76.5%)	0.809	0.413
female	n (%)	23 (25.3%)	6 (30%)	9 (24.3%)	8 (23.4%)
History of alcohol abuse	n (%)	28 (30.8%)	0	9 (24.3%)	19 (55.9%)	0.000 *	0.000 *
Index-OPSCC localization
Tonsils	n (%)	79 (86.8%)	19 (95%)	34 (91.9%)	26 (76.6%)	0.050 *	0.281
Base of tongue	n (%)	9 (9.9%)	1 (5%)	3 (8.1%)	5 (14.7%)	0.286	0.446
Soft palate	n (%)	1 (1.1%)	-	-	1 (2.9%)	-	-
Pharyngeal wall	n (%)	2 (2.2%)	-	-	2 (5.9%)	-	-
Death due to OPSCC or associated cancer	n (%)	17 (18.7%)	2 (10%)	5 (13.4%)	10 (29.4%)	0.054	0.226
Index-UICC stadium
I	n (%)	15 (16.5%)	3	5	7	0.56	1
II	n (%)	17 (18.7%)	5	6	6	1	0.345
III	n (%)	11 (12.1%)	0	4	7	0.093	0.06
IVa	n (%)	47 (51.6%)	12	22	13	0.055	0.47
IVb	n (%)	1 (1.1%)	0	0	1	-	-
Treatment
Surgery	n (%)	91 (100%)	20 (100%)	37 (100%)	34 (100%)	1	1
RT ± chemo	n (%)	60 (65.9%)	13 (65%)	25 (67.6%)	21 (61.8%)