Table 2.
Overview of the number and locations of SPT of HPV-positive nonsmokers, HPV-positive smokers, and HPV-negative patients. The table compares the number of SPT, as well as the number of SPT at specific locations, between HPV-positive and HPV-negative patients, smokers and nonsmokers, and between HPV-positive nonsmokers and HPV-positive smokers using a two-sided Fisher’s exact test. Results statistically significant at the 5% significance level are marked with *. Abbreviations: HPV = human papillomavirus, NS = nonsmokers, S = smokers, + = positive, − = negative, SPT = second primary tumors.
| Number and Localization of SPT | 1 | 2 | 3 | 4 | 5 | 6 | 7 |
|---|---|---|---|---|---|---|---|
| Total Cohort n = 91 |
HPV+ NS n = 20 |
HPV+ S n = 37 |
HPV− n = 34 |
p-Values HPV+ vs HPV− (n = 57 vs. n = 34) |
p-Values S vs. NS (n = 69 vs. n = 22) |
p-Values HPV+ NS vs. HPV+ S (n = 20 vs. n = 37) |
|
| SPT | |||||||
| Yes | 21 (23.1%) | 4 (20%) | 4 (10.8%) | 13 (38.2%) | 0.011 * | 0.772 | 0.432 |
| SPT localization | |||||||
| Oral cavity | 4 (4.4%) | 1 (5%) | 0 | 3 (8.8%) | - | - | - |
| Oropharynx | 5 (5.5%) | 0 | 2 (5.4%) | 3 (8.8%) | 0.965 | 0.020 * | 0.429 |
| Larynx | 3 (3.3%) | 0 | 1 (2.7%) | 2 (5.9%) | - | - | - |
| Hypopharynx | 2 (2.2%) | 0 | 0 | 2 (5.9%) | - | - | - |
| Esophagus | 1 (1.1%) | 0 | 0 | 1 (2.9%) | - | - | - |
| Lung | 6 (6.6%) | 3 (15%) | 1 (2.7%) | 2 (5.9%) | 0.146 | 0.053 | 0.486 |